"I can't believe I'm having to write this, but my father, Edward Lodewijk Van Halen, has lost his long and arduous battle with cancer this morning," Wolf Van Halen wrote in a message on Twitter with a picture of the rocker who was 65.
"He was the best father I could ever ask for," he added. "Every moment I've shared with him on and off stage was a gift.
"My heart is broken and I don't think I'll ever fully recover from this loss. I love you so much, Pop."
Eddie Van Halen was part of the Van Halen group, considered one of the greatest rock bands of all time.
The renowned guitarist was born in the Netherlands and raised in California during which he formed the rock band with his older brother Alex in the early 1970s. Not long after the band’s formation, they quickly earned a fan base.
He was famous for what became known as "finger tapping" — playing the guitar with two hands, like a piano.
He was also known for his guitars, including one named Frankenstein which he pieced together from part of other instruments.