"The hard truth is, you won't be safe in Joe Biden's America," said the 61-year-old Pence.
Pence's address came amid a new flare-up of racial tensions in the United States, with protests spreading over the latest police shooting of an African-American man, Jacob Blake, in Kenosha, Wisconsin.
Trump announced he is sending in additional federal forces to quell unrest in the Midwestern city, where two people were shot dead during anti-police protests Tuesday.
A 17-year-old has been arrested on murder charges.
Read also: 17-Year-Old Kyle Rittenhouse Arrested for Homicide as Unrest in Kenosha Continues
Addressing the latest unrest, Pence struck a tough tone.
"Let me be clear. The violence must stop whether in Minneapolis, Portland or Kenosha," he said.
"We will have law and order on the streets of this country for every American."
Touting Trump's strong economic record before the Covid-19 epidemic struck and his ongoing efforts to revive it — Pence urged voters to ask themselves "who do you trust to rebuild this economy?"
A former governor of Indiana, the evangelical Christian Pence has taken on the role of calm counterweight to Trump's constant drama.