Since stepping down earlier this year, the couple has made several comments on race issues which are usually avoided by the British Royal Family.
Prince Harry and Meghan Markle told The Evening Standard newspaper that structural racism holds back people of color.
On the topic of structural racism, the British Prince added that Britain could be a better place if white people understood more about those "of a different colored skin".
"For as long as structural racism exists, there will be generations of young people of color who do not start their lives with the same equality of opportunity as their white peers," the couple wrote in an article for the paper.
The Duke and Duchess of Sussex stepped down from their roles as working members of the royal family at the end of March and moved to California.
Prince Harry, 36, told the Standard he had been awakened to the issues facing Black and other ethnic minorities since meeting Meghan Markle, whose father is white and mother is African American.
"I wasn’t aware of so many of the issues and so many of the problems within the UK and also globally as well. I thought I did but I didn’t," he said.