The call comes as Greek authorities promised 12,000 migrants and asylum seekers left homeless after a fire broke out at the Moria camp on the island of Lesbos.
The massive blaze gutted the overcrowded camp though authorities said that residents would be moved to a new tent city.
The Greek Prime Minister blamed some residents at the Moria camp in Lesbos for purposefully starting the blaze in an attempt to blackmail his government.
However, the PM said that the incident could be an opportunity to improve how the EU addresses the key challenge on migration.
“It (the burning of Moria) was a tragedy. These images were bad. It was a warning bell to all to become sensitized. Europe cannot afford a second failure on the migration issue,” Mitsotakis said Sunday at a press conference in the northern city of Thessaloniki.
Human rights activists have long deplored the squalor at the Moria camp in Lesbos, which was built to house 2,750 but was filled with some 12,500 people who fled across the sea from Turkey.
Since the fires, which came after the camp faced a coronavirus lockdown, thousands of people have camped out in the open on a highway near Moria under police guard.
Many have protested the Greek government for refusing to allow the homeless migrants to leave Lesbos for the Greek mainland.